Sep 2026
CAIX-targeted red-light-activated osmium(II) polypyridyl photosensitizer inducing pyroptosis and ferroptosis to combat hypoxia tumors.
To overcome the limitations imposed by hypoxia in photodynamic therapy (PDT), we rationally designed and synthesized three carbonic anhydrase IX (CAIX)-targeted osmium(II) polypyridyl complexes (Os1-Os3) by conjugating a benzenesulfonamide CAIX inhibitor to the photosensitizer core. Among them, Os3 exhibited excellent...
Qin Gong, Xiu-Qin Su, Shan Jiang et al.
· Dalton Transactions · 0 citations