Neutrophil–microglia communication through the C3–C3aR1 axis contributes to secondary neuroinflammation after traumatic brain injury
Traumatic brain injury (TBI) triggers a rapidly evolving neuroinflammatory response that contributes to secondary brain injury. Although infiltrating leukocytes and resident microglia are both prominent components of this response, the cellular signals that connect peripheral immune-cell recruitment to microglial s...