Tetrandrine attenuates diabetic kidney disease by suppressing the TLR4-NF-κB-NLRP3 inflammatory signaling pathway in proximal tubular cells.
BACKGROUND Diabetic kidney disease (DKD) involves persistent tubular inflammation. Tetrandrine (Tet), a bioactive alkaloid from Stephania tetrandra S. Moore, has renoprotective potential, but its effects on TLR4-associated inflammatory signaling remain incompletely understood. METHODS Male KK-Ay mice received Tet (10...