Chen-Yang Wang

Structurally diverse indole alkaloids from an endolichenic fungus Aspergillus sp. with antiproliferative activity against non-small cell lung cancer cells.

Chemical investigation of the endolichenic fungus Aspergillus sp. TJ403-YJ22 led to the isolation and characterization of twelve new indole alkaloids, asperkaloids A-L (1-12). Compounds 1-10 represent non-paspaline-type indole-diterpenoids, whereas 11 and 12 are polyketide-indole hybrids. Notably, compounds 1 and 2 pos...