Chem-Stamp Empowered Discovery of a Novel ATRA-Based LDLR Up-Regulator for the Treatment of Atherosclerosis.
Natural products and their derivatives have long served as a prolific reservoir for drug discovery. All-trans retinoic acid (ATRA) regulates lipid metabolism and shows anti-atherosclerotic potential, but its application is limited by poor drug-like properties and retinoid-related toxicity. Here, an allene-based Chem-St...