QUALITY BY DESIGN-DRIVEN REVERSED PHASE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD DEVELOPMENT, OPTIMIZATION, AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF SOFOSBUVIR AND VELPATASVIR IN BULK AND TABLET DOSAGE FORM
Objective: To create and validate a stability-indicating Reversed Phase-High Performance Liquid Chromatography(RP-HPLC) technique based on Quality by Design (QbD) for the simultaneous measurement of Sofosbuvir (SOF) and Velpatasvir (VEL) in pharmaceutical dosage forms and bulk. Methods: A QbD approach using Central Com...