Cheng-Bin Lu

ZBP1 and IFI16: novel innate sensors and inflammation regulation under infection stress

The innate immune system is the first line of defense against infection, using pattern recognition receptors to sense pathogens and abnormal host-derived nucleic acids. Among these, Z-DNA–binding protein 1 (ZBP1) and interferon gamma–inducible protein 16 (IFI16) are two important nuclear and cytosolic nucleic acid sens...