Open access
Aug 2026
Phototherapy-responsive nanoplatform with hydrogel delivery potentiates immunotherapy and inhibits lung metastasis in osteosarcoma via synergistic glycolysis inhibition and vascular normalization
The immunosuppressive tumor microenvironment (ITME)—marked by acidosis and hypoxia—persists as a critical barrier to cancer immunotherapy, especially for osteosarcoma. Herein, an injectable pH-responsive nanocomposite hydrogel (OP@NPs) is presented to overcome this challenge via coordinated metabolic modulation, vascul...
Meng-Chao Dong, Ting-Ting Zhang, Yi-Chun Huang et al.
· Journal of Nanobiotechnology · 0 citations