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Author

Cheng-Han Luo

2 papers indexed here

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Open access Oct 2026

Machine learning and multi-omics analyses reveal CLDN1 as a candidate marker associated with colorectal cancer invasion and nutlin-3a (-) response.

OBJECTIVE Colorectal cancer (CRC) is molecularly, cellularly and spatially heterogeneous, and current staging systems and biomarkers incompletely explain prognosis and treatment response. This study integrated transcriptomics, machine learning, single-cell RNA sequencing, spatial transcriptomics and in vitro experiment...

Wenqi Shan, Qian-Yu Li, Wei Yuan et al. · 0 citations
Open access Sep 2026

Tumor-associated osteoclasts converge on a matrix-sulfation program across human bone tumors

Introduction Osteoclasts mediate the bone destruction that drives much of the morbidity of giant-cell tumor of bone, osteosarcoma, and skeletal metastasis, yet these large multinucleated cells are lost in droplet single-cell data and have never been defined as a disease cell state. Methods We reanalyzed 378,936 cells f...

Meng-Yuan Lei, Shu-Ya Chang, Ning-Jing Lei et al. · 0 citations

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