Author

Cheng-Hua Liu

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Review Open access Aug 2026

Development and clinical application of recombinant polyclonal antibodies

Monoclonal antibodies (mAbs) have transformed the treatment of cancer and immune disorders, but their single-target nature limits efficacy against heterogeneous tumors and mutating pathogens. Recombinant polyclonal antibodies (RPABs)—defined as mixtures of typically 2–25 defined mAbs produced as a single drug substance...

Jiaqi Jin, Guo-Jiang Chen, Fenghao Peng et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

Benchmarking antibody modeling tools across structure prediction, docking, and paratope–epitope interface analysis

This work evaluated ImmuneBuilder, IgFold, AlphaFold3, GRAMM, and dyMEAN on 50 non-redundant humanized antibody–antigen complexes using multiple retained predictions and paired statistical testing, finding all three antibody structure predictors were accurate.

Ze-Yuan Yu, Ji-Lei Wu, Zi-Yao Ning et al. · Bioinformatics Advances · 1 citation