Cheng-I Lee

Discovery of Potential Prion Fibril Inhibitors From Curcumin‐Like Compounds via Structure‐Based Virtual Screening and Molecular Dynamics Simulations

It is suggested that curcumin‐like compounds modulate fibril stability through binding to a specific hydrophobic hotspot rather than directly disrupting β‐sheet structures, providing mechanistic insights into their potential as prion fibril inhibitors.