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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Cheng Shi

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Jul 2026

AI-Driven Discovery of a Hydrophobic-Tag Degrader Targeting NSD3 for Lung Squamous Carcinoma Therapy.

Nuclear receptor-binding SET domain protein 3 (NSD3) is a histone H3K36 methyltransferase implicated in lung squamous cell carcinoma, yet chemical targeting is challenging due to the shallow PWWP reader pocket. Here, we report XSY12, a hydrophobic-tag degrader of the NSD3 PWWP domain that enables cellular NSD3 depletio...

Si-Yu Xiu, Zhenyu Jia, Qi Li et al. · 0 citations
Open access Aug 2026

A closed-loop reinforcement learning framework for rapid compound directed optimization

Generative artificial intelligence (AI) holds transformative potential for drug discovery, yet existing architectures typically operate in open loops without experimental feedback. Here we introduce rapid compound directed optimization (RCDO), a closed-loop reinforcement learning framework that accelerates the optimiza...

Han Wang, Dehua Lu, Weiping Lyu et al. · 0 citations

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