Review
Open access
Sep 2026
From Molecular Recognition to Clinical Readout: Design Principles for Functional Nucleic Acid–Material Biosensors in Medical Diagnostics
Across the literature, reliable performance depends on selective recognition before high-gain reactions, compatibility between amplification products and interfaces, explicit controls for inhibition and leakage, and validation across independent lots and representative clinical populations.
Qi-Ming Chen, Cheng-Tian Xue, Yuan-Long Hu et al.
· Molecules · 0 citations