Open access
Sep 2026
Therapeutic Potential of iPSC-Derived TH⁺/FOXA2⁺ Neuronal Extracellular Vesicles in Parkinson’s Disease Revealed by Organoid and Rodent Models
Background Parkinson’s disease (PD) is characterized by the progressive loss of midbrain dopaminergic (DA) neurons and aberrant α-synuclein (α-syn) aggregation, yet disease-modifying therapies that simultaneously retard neurodegeneration and foster regeneration remain lacking. Methods In this study, we isolated extrace...
Zhen Qi, Xiao-Wen Li, Xiao Jin et al.
· bioRxiv · 0 citations