Cheng-Wei Ju

Lineage tracing reveals asynchronous fate restriction in mouse embryos and stem cell-derived embryo models

A lineage-resolved view of embryogenesis reveals that cell identity alone predicts neither developmental ancestry nor the timing of fate restriction, and builds FateVec, an analysis framework that infers fate-bias dynamics and lineage-associated transcriptional programs from reconstructed phylogenies.

Lineage tracing reveals asynchronous fate restriction in mouse embryos and stem cell-derived embryo models

Myeloid reprogramming generates myeloid-derived activating cells to potentiate radiotherapy and suppress metastasis.

These findings define MDACs as an immunogenic myeloid subset and establish myeloid reprogramming as a strategy to improve radiotherapy-immunotherapy outcomes.