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Author

Chengwei Yang

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Review Open access Sep 2026

Transposable Element Dysregulation in Hepatocellular Carcinoma: Epigenetic Mechanisms, Immune Remodeling, and Translational Opportunities.

Hepatocellular carcinoma (HCC) commonly develops in the context of chronic liver injury, viral hepatitis, metabolic dysfunction, alcohol-related liver disease and cirrhosis. Although immune checkpoint inhibitor-based combination therapies have improved the treatment of unresectable HCC, primary and acquired resistance...

Xiao-Peng Chen, Bao-Ding Li, Hao Chai et al. · 0 citations
Review Open access Jul 2026

Deciphering immunosuppressive niches by spatial single-cell proteomics: spatial interaction networks and translational opportunities

Current research findings on the cellular composition, spatial structure, and regulatory mechanisms of the immunosuppressive microenvironment are summarized and the emerging clinical value of space biomarkers and interaction networks in patient stratification, therapeutic target identification, and precision immunother...

Hao Chai, Lang Wu, Xiaopeng Chen et al. · 0 citations

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