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Cheng-Yu Yang

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Sep 2026

Molecular basis of metal transport by human ZnT10.

Manganese is essential for immunity and neurological health, and its dysregulation causes Parkinsonism and dystonia. We present cryo-electron microscopy (cryo-EM) structures of human ZnT10, a Mn2+/Zn2+ transporter, in symmetric inward-facing and asymmetric inward/outward states. Conformational shifts in TM1, TM2, TM4,...

Hong-Chen Mu, Cheng-Yu Yang, Ruo-Yang Feng et al. · 0 citations

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