Melatonin ameliorates renal fibrosis by disrupting the DANCR/QK-mediated stabilization of MALAT1 and inhibiting Galectin-3-dependent macrophage polarization.
BACKGROUND Renal fibrosis drives kidney dysfunction in chronic kidney disease via inflammation, oxidative stress, and fibroblast activation. Deciphering its mechanisms is vital for antifibrotic therapy. RESEARCH DESIGN AND METHODS A mouse model of renal fibrosis was established via unilateral ureteral obstruction, wi...