Development, Evaluation, and Multicenter Clinical-Trial Application of an Artificial Intelligence-Assisted MRI Method for Quantitative Knee Cartilage Morphometry
Objective: To develop and evaluate an AI-assisted MRI method for quantitative knee cartilage morphometry in a multicenter phase III knee osteoarthritis trial. Methods: AI pre-segmentation used 3D full-resolution nnU-Net. Version 1.0 used separate femorotibial- and patellar-cartilage models, whereas version 2.0 used a u...