Macrophage-Derived Glycoprotein Nonmetastatic Melanoma Protein B Attenuates Cardiac Dysfunction by Promoting Vascular Endothelial Growth Factor-Independent Angiogenesis.
BACKGROUND Pressure overload-induced heart failure involves maladaptive cardiac remodeling and inadequate angiogenesis. The limitations of VEGF (vascular endothelial growth factor)-based therapies underscore the need to identify alternative angiogenic pathways. GPNMB (glycoprotein nonmetastatic melanoma protein B) is a...