Jul 2026
Structure-Guided Discovery of Novel Dual-Site FEM1B Ligands and Assessment of Their Use in Targeted Protein Degradation.
This work developed FL47, a dual-site ligand that combines extensive noncovalent interactions with targeted covalent engagement that exhibits submicromolar affinity, robust cellular target engagement, and markedly reduced cytotoxicity relative to previously reported covalent recruiters.
Ling-xiang Xu, Ruyi Huang, Yu-Ying Ma et al.
· Journal of Medicinal Chemist... · 0 citations