Chenyu Lou

Repurposing ritonavir to induce proteasomal degradation of IE1 for inhibition of human cytomegalovirus replication.

Human cytomegalovirus (HCMV) is a major pathogen affecting immunocompromised individuals. Current antiviral drugs target the mid-to-late stages of viral replication but are limited by toxicity and drug resistance. The IE1 protein serves as a key early regulator of HCMV replication; however, it has long been considered...