Respiratory syncytial virus (RSV) affects all ages, with infants and older adults most affected by severe disease. The RSV prevention landscape includes 39 candidates in clinical development, alongside setbacks such as the discontinuation of a promising paediatric live-attenuated vaccine candidate. Several products hav...
Rosalie W. Groenendijk, Zazie Franck, R. Baral et al.· Lancet. Infectious Diseases...· 0 citations
OBJECTIVES
Pneumococcal conjugate vaccines (PCV) have reduced antimicrobial-resistant invasive pneumococcal disease (IPD) globally. We evaluated trends in antimicrobial-resistant IPD and pneumococcal lineages before and after PCV13 introduction in South Africa.
METHODS
We analysed national, laboratory-based IPD surve...
Cebile Lekhuleni, K. Ndlangisa, L. De Gouveia et al.· Journal of Infection· 0 citations
SARS-CoV-2 evolution enhanced viral fitness and immune evasion, extending the COVID-19 pandemic and resulting in millions of excess deaths. Viral diversity is generated within infected individuals, yet the timing and interplay of viral and immunological forces that drive transmissible evolution are incompletely underst...
Katherine Owens, Pierce E. Radecki, S. Tempia et al.· bioRxiv· 0 citations
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