Oncogenes and tumor-suppressor genes play opposing roles in cancer biology to promote and restrict growth, respectively. Codon usage patterns interface with tRNA modifications to control translation, leading to gene-specific codon signatures with regulatory potential. As such, codon-biased translational regulation has...
Chetna Mathur, Evan T. Davis, Dylan J. Ehrbar et al.· bioRxiv· 0 citations
Escherichia coli uses wobble uridine (U34) modifications to tune codon decoding, but how individual tRNA writer enzymes shape gene expression remains unclear. Here, we identify MnmA, the U34 thiolation enzyme for tRNALys, tRNAGln, and tRNAGlu, as a central regulator linking codon-directed translation to regulon control...
H. Omeoga, Dylan J. Ehrbar, Chetna Mathur et al.· bioRxiv· 0 citations
This work develops a potential method to construct more biostable DNA nanostructures and 3D crystals in a simple one-tube process by assembly of a wide variety of DNA nanostructures and 3D crystals in a hydrated ionic liquid instead of magnesium at constant moderate temperatures.
