Glial-adjusted residual transcriptomics with leave-one-out transcriptome-wide association study influence analysis prioritizes GALNT6 and other high-impact genes in Alzheimer's disease
Bulk transcriptomic studies of Alzheimer's disease are difficult to interpret because the diseased brain is not only transcriptionally altered, but structurally remodeled. Neuronal and synaptic loss, reactive gliosis, and vascular or extracellular-matrix changes can all shift measured expression. To reanalyz...