Author

Chia-Wei Li

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Open access Aug 2026

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

ABSTRACT Despite advancements in immune checkpoint blockade (ICB) therapy, breast cancer shows limited response to anti‐PD1/PD‐L1 treatments, emphasizing the need for alternative ICB targets. Here, we reveal that endocrine therapeutics, specifically tamoxifen, create an immunosuppressive yet primed tumor microenvironme...

M. A. Aberin, Saurabh Singh, Soumya Chatterjee et al. · Advancement of science · 0 citations

Open access Aug 2026

Smyca-FOXM1 ribonucleoprotein complex promotes homologous recombination and tumor immune evasion to define a therapeutic target of triple-negative breast cancer

This study identifies an unprecedented role of Smyca in HR repair to promote TNBC survival and immune evasion in response to therapy and suggests Smyca as a potential target for sensitizing TNBC to chemotherapy, PARPi, or immunotherapy.

Han Chen, Keng-Hao Chang, Sin-Rong Lee et al. · Journal of Biomedical Scienc... · 0 citations