The prevalence and impacts of NUDT15 variants in pediatric-onset inflammatory bowel disease patients in Taiwan.
BACKGROUND Thiopurines are important therapeutic agents for patients with inflammatory bowel disease (IBD), and the Nudix hydrolase 15 (NUDT15) gene has been reported to be associated with the safety of thiopurine use. We investigated the prevalence of NUDT15 variants and their impacts in the pediatric-onset IBD group...