Chinatsu Mori

Distribution-Constrained Optimization for Reliable ML-Guided 5′UTR Sequence Design

The 5′ untranslated region (5′ UTR) shapes translation initiation, so its design is central to mRNA therapeutics and to improving protein-production cell lines. Deep-learning models that predict translation efficiency, measured as mean ribosome load (MRL), from the 5′ UTR sequence have been combined with genetic algori...