Author

Ching-Seng Ang

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Open access Aug 2026

Rb-driven transcription limits its tumour-suppressive effects in breast cancer

The retinoblastoma protein (Rb) is a tumour suppressor best known for repressing E2F transcription factors and halting cell cycle progression1. In hormone receptor-positive (HR+) breast cancer, CDK4/6 inhibitors activate Rb by preventing its phosphorylation, forming a key component of current endocrine therapy regimens...

April C. Watt, Antonio Ahn, Catherine Blyth et al. · Nature · 2 citations

Open access Jul 2026

Complement, coagulation and NET pathway activation underlies early host response to blowfly (Lucilia cuprina) infestation.

Findings in this study suggest that breech strike resistance is unlikely to be associated with differences in skin protein expression during a short infestation, and larval ES products also showed no significant differences between resistant and non-selected sheep.

Sugandhika G. Welikadage, Y. Yang, Shilpa Kapoor et al. · Parasites & Vectors · 0 citations