Chinmoy Patra

A Dual-Function Guanidinium Scaffold for Copper sequestration and Redox Protection in Wilson disease Models.

Wilson disease (WD) is caused due to mutations in the copper ATPase gene ATP7B, resulting in accumulation of copper and the consequent disruption of cellular redox balance through reactive oxygen species generation. Current therapies mainly depend on copper chelation to lower metal burden which sometimes also strip cop...