Cho Kun

Backbone-matched comparison of two trastuzumab-based antibody–drug conjugates: payload localization and gas-phase heterogeneity of trastuzumab deruxtecan and trastuzumab rezetecan

Antibody–drug conjugates (ADCs) are biotherapeutics that are structurally heterogeneous due to the way each ADC is formed. Therefore, complementary analytical approaches need to be used in order to achieve a complete characterization of all aspects of the structure of these biotherapeutics. This project created a multi...