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Author

Chong-Hui Hu

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2 papers indexed here

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Sep 2026

circMTHFD1L-driven lipid metabolism in Cancer-associated fibroblasts confers oxaliplatin resistance in pancreatic cancer through O-GlcNAcylation-dependent chromatin recruitment of Ku70.

Platinum-based chemotherapy resistance severely limits therapeutic efficacy and survival in pancreatic ductal adenocarcinoma (PDAC), yet the role of cancer-associated fibroblasts (CAFs) in driving this resistance remains elusive. We screened and validated circMTHFD1L (hsa_circ_0078269) as a stromal circRNA that is mark...

Qing Tian, Tian-Hao Huang, Ning-Ning Zhang et al. · 0 citations
Open access Sep 2026

Biological aging, circulating lipid biomarkers and pancreatic diseases: a prospective cohort study based on the UK Biobank

Background Biological aging refers to gradual declines in overall physiological function and can raise susceptibility to diseases. However, whether biological age acceleration is associated with pancreatic diseases remains unclear. Methods In UK Biobank, 326,873 adults recruited in 2006–2010 were included. Klemera-Doub...

Hang Zhang, Jun-Wei Huang, Pei-Yu Lin et al. · 0 citations

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