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Author

Chong-Yang Han

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Review Sep 2026

GLP-1 receptor agonists and podocyte senescence in diabetic kidney disease: structural pharmacology, mechanistic evidence, and multi-receptor agonism.

Diabetic kidney disease (DKD) is a major cause of chronic kidney disease and kidney failure worldwide. Podocyte senescence is increasingly recognized as a contributor to diabetic glomerular injury, but its importance in human DKD and its modulation by glucagon-like peptide-1 receptor agonists (GLP-1RAs) remain incomple...

Hong-Yu Yue, Yu Wang, Xing-Yu Guo et al. · 0 citations
Open access Sep 2026

Lysine-specific demethylase 3A (KDM3A) protects against ovarian dysfunction in premature ovarian insufficiency by transcriptional activation of ATP-binding cassette sub-family A member 7 (ABCA7)-mediated mitochondrial homeostasis

Premature ovarian insufficiency (POI) is a heterogeneous disorder characterised by accelerated follicular depletion and ovarian dysfunction before age 40, yet effective therapeutic strategies remain limited. Here we identify the histone demethylase KDM3A (lysine‑specific demethylase 3A) as a critical protective factor...

Xiang-Rong Cui, Chong-Yang Han, Pu-Hua Zhang et al. · 0 citations

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