Open access
Jul 2026
Transcriptomic and metabolomic analyses reveal that lobeglitazone ameliorates hepatic steatosis in rats concurrent with regulation of mitochondrial pyruvate metabolism.
BACKGROUND AND PURPOSE Lobeglitazone is a thiazolidinedione and PPARγ agonist that improves metabolic parameters and hepatic steatosis, but its mechanisms are not fully understood. This study investigated the effects of lobeglitazone on hepatic transcriptomic and metabolic profiles in a rat model of obesity and Type 2...
Hyekyung Yang, S. Son, Youngmi Song et al.
· British Journal of Pharmacol... · 0 citations