Christa N. Molé

Cold-adapted RNA polymerase from Pseudomonas phage Njord improves synthesis of therapeutic mRNA

Significance Bacteriophage T7 RNA polymerase (T7 RNAP) has enabled the development of mRNA vaccines and remains central to the manufacture of this therapeutic modality. Here, we report on a natural homolog of T7 RNA polymerase, Njord RNA polymerase, which supports high-yield RNA synthesis at substantially lower tempera...