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Author

Christian A. Howard

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Open access Oct 2026

Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial-immune cell interactions.

The distal small intestine has a vital role in host physiology through its regulation of nutrient and fluid homeostasis. Despite being affected in Crohn's disease and serving as a major target for a range of infections, we know relatively little about the complexity of cellular responses and cell-cell communication in...

A. Hart, Maria I. Merolle, Christian A. Howard et al. · 0 citations
Open access Sep 2026

Impaired regulation by purinergic signaling axis contributes to CD8+ T cell dysregulation in STAT3 gain of function

It is found that in patients with STAT3 GOF, CD8+ T cells exist in an activated state and a dysregulated purinergic signaling axis plays a key role in CD8+ T cell dysregulation in STAT3 GOF and may have implications for other rare monogenic immune disorders and common inflammatory disorders.

Jose S. Campos Duran, Montana Knight, Samir U. Sayed et al. · 0 citations

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