Cholesterol restores cortico-striatal synaptic connectivity in Huntington's disease through BDNF-TrkB signalling, supporting a role for cholesterol pathways implicated by human genetic modifier studies.
Cortico-striatal synaptic dysfunction is an early hallmark of Huntington's disease (HD), yet the mechanisms underlying synapse loss and its reversibility remain poorly understood. Brain cholesterol is essential for neuronal and synaptic function, and dysregulated cholesterol metabolism has emerged as a key feature of H...