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Author

Christian Lesterlin

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Open access Sep 2026

Model-based evaluation of Targeted-Antibacterial-Plasmids (TAPs) transfer kinetics and resensitization of pOXA-48 carbapenem-resistant Escherichia coli

Background Targeted-Antibacterial Plasmids (TAPs) are engineered mobile genetic elements that use bacterial conjugation to deliver selective CRISPR/Cas9 antibacterial activity against a specific target strain. Yet, the efficiency of TAPs is typically evaluated at a single time point, whereas the success of TAP-mediated...

S. Marolleau, J. Moreau, J. Buyck et al. · 0 citations
Open access Jul 2026

Widespread immune systems protect bacteria against conjugative plasmids

A large-scale analysis of 364 diverse strains of the opportunistic pathogen Acinetobacter baumannii as recipients of the broad-host-range conjugative plasmids R388 and RP4 reveals an additional layer of bacterial immunity directed at a class of genetic elements driving dissemination of antibiotic resistance.

L. Poiré, J. Baltenneck, Salomé Guillory et al. · 0 citations

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