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Author

Christina M. Coughlan

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Open access Sep 2026

Region-specific human cardiac extracellular vesicles differentially regulate mitochondrial function

Aim: The human heart contains two major mitochondrial subtypes, subsarcolemmal (SSL), fueling surface ion channels, and interfibrillar (IF), fueling interior contractile machinery. This study investigated whether the distinct extracellular vesicles (EVs) that we determined to be associated with these regions could infl...

Genevieve C. Sparagna, Christina M. Coughlan, Hailey L. Chapman et al. · 0 citations
Open access Jul 2026

Type 1 diabetes is associated with higher plasma levels of biomarkers of neurodegeneration and neuroinflammation

T1D is associated with a greater burden of plasma biomarkers of neurodegeneration and neuroinflammation, and microvascular complications such as DR and impaired kidney function may contribute to this burden.

Meghan E Pauley, Christina M. Coughlan, Fran Dong et al. · 0 citations

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