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Author

Christina S. Leslie

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Sep 2026

Abstract B009: Invasion status parses composition of the human pancreatic cancer perineural niche

The peripheral nervous system innervates the pancreatic ductal adenocarcinoma (PDAC) microenvironment, and perineural invasion (PNI) of cancer cells correlates with metastatic burden and poor outcomes. Though PDAC innervation is near-universal and the majority of PDAC patients harbor PNI, the cellular and molecular c...

Zainab Hussain, Dig Vijay Kumar Yarlagadda, Qian-Zi Li et al. · 0 citations
Open access Aug 2026

Developmental reversion underlies resistance to immune checkpoint blockade in kidney cancer

An atlas of ccRCC tumors is assembled combining single-cell RNA sequencing and imaging-based spatial transcriptomics to suggest reversion to embryonic nephrogenesis as a defining feature of persister cells in ccRCC, nominating the nephrogenic developmental program and its associated inhibitory checkpoint repertoire as...

Dig V.K. Yarlagadda, Zhenghan Wang, Hui Jiang et al. · 0 citations
Open access Jul 2026

An encyclopedia of human enhancer–gene regulatory interactions

An encyclopedia of enhancer–gene regulatory interactions in the human genome is built, revealing global properties of enhancer networks, identifying differences in regulatory complexity across genes, and improving analyses linking noncoding variants to target genes and cell types for common, complex diseases.

A. Gschwind, Kristy S. Mualim, Alireza Karbalayghareh et al. · 6 citations

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