Open access
Aug 2026
SAP loss limits anti-insulin atypical B cell activation and pro-inflammatory CD8 T cells despite preserved Tfh responses to protect against type 1 diabetes
The essential role of SAP in mediating proinflammatory, anti-insulin B-T interactions to support T1D is highlighted, which led to reduced pro-inflammatory CD8+ T cell formation and islet-reactive progenitor exhausted CD8+ T cells in pancreata.
Landon M. Clark, Dudley H. McNitt, Jack C. McAninch et al.
· bioRxiv · 0 citations