Christine Jorge

Automated High-Throughput Ligand-Detected NMR for Medicinal Chemistry Hit Triage and Binding Assessment

Early discovery campaigns routinely generate screening hits whose progression is limited by uncertain aqueous solubility, chemical integrity, and target engagement. We report a fully automated, ligand-detected high-throughput NMR (HT-NMR) workflow, applicable to aromatic-ring-containing compounds common to high throu...