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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Christoffer G. Alexandersen

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Preprint Aug 2026

Activity-dependent epidemic spreading on multiscale brain networks predicts Alzheimer's disease progression

Neurodegenerative diseases can be viewed as spreading processes on brain networks, in which pathological proteins propagate between anatomically connected brain regions. Mathematical models have been used to study this process, but they generally ignore the influence of neuronal activity, even though experimental studi...

Christoffer G. Alexandersen, Suman S. Kulkarni, Jessica T. Davis et al. · 1 citation
Preprint Aug 2026

Hysteresis and multistability in network spreading with neuronal activity feedback

Spreading processes on networks often interact with other dynamics on the same nodes. Neurodegenerative disease provides one example: pathological proteins spread through anatomical connections, while neuronal activity influences and is altered by their spread, forming a spreading-activity feedback loop. However, model...

Christoffer G. Alexandersen, Dani S. Bassett · 0 citations

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