Comprehensive cardiac, vascular, and pulmonary characterization of a cardiometabolic HFpEF model.
BACKGROUND Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome in which translational progress is limited by experimental models that insufficiently reflect the cardiometabolic phenotype while affecting endogenous endothelial function. We aimed to characterize a cardiometabolic "two-hit"...