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Christopher G. O'Neill

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Oct 2026

Programmed cell death protein 1 (PD-1) regulates metabolic activity of regulatory T cells in ischemia-induced acute kidney injury.

It is demonstrated that PD-1 knockout mice have worse renal function after IRI when compared to wild-type mice, and the metabolic vulnerability of PD-1-deficient Tregs is revealed, highlighting the critical role of PD-1 in Treg-mediated nephroprotection.

Oliver B. Pelletier, Murat Dogan, Christopher G. O'Neill et al. · 0 citations

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