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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Christopher M. Depner

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Open access Jul 2026

Internal Circadian Misalignment of the Human Metabolome Links Night Shiftwork to Metabolic Impairment

24-h modeling analyses identified metabolite rhythms influenced by circadian versus behavioral cycles (sleep, food intake) and quantified internal circadian misalignment using acrophase shifts and suggests dysregulated pyrimidine and bile acid–microbiome pathways as potential mechanisms linking circadian misalignment t...

Michelle Kubicki, Andrew W. McHill, Edward L. Melanson et al. · 0 citations

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