Author

Christopher O. Barnes

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Open access Oct 2026

Structure-guided vaccination elicits broadly neutralizing antibodies targeting the HIV-1 silent face

An effective HIV-1 vaccine will likely require broadly neutralizing antibodies (bnAbs) targeting multiple complementary epitopes on the Envelope (Env) glycoprotein. Donor-derived bnAbs targeting the conserved silent face (SF) epitope complement established bnAb classes, but the maturation pathways underlying SF bnAb de...

Joshua J. Carter, M. B. Palacio, Mark E. Berlaga et al. · bioRxiv · 0 citations

Open access Sep 2026

Structural basis of diverse antibody recognition of conserved coronavirus spike S2 epitopes that contribute to protective immunity

These findings expand the genetic, structural and functional landscape of human antibody responses to conserved coronavirus S2 epitopes and demonstrate that CH-directed antibodies can contribute to protective immunity through Fc-dependent mechanisms not predicted by in vitro neutralization or conventional in vitro Fc e...

Adonis A. Rubio, Virginia Crivelli, Václav Hönig et al. · bioRxiv · 0 citations

Open access Sep 2026

Dissociation kinetics and avidity gate SARS-CoV-2 neutralization by HR2 stem helix antibodies

It is shown that plasma IgG reactivity to this region remains rare, even after repeated antigen exposure, and kinetic and avidity constraints governing neutralization at the HR2 stem helix and position hr2.016 as a resilient therapeutic candidate.

Virginia Crivelli, Concetta Guerra, M. Abernathy et al. · bioRxiv · 0 citations