Christopher S. Garris

Albumin uptake through FcRn promotes tumor-associated macrophage maturation and albumin-bound immunotherapy response.

Serum albumin accumulates in tumors and is widely exploited for drug delivery, but its accumulation and function in nonmalignant cells are less understood. Here, we show that tumor-associated macrophages (TAMs) are the dominant nonmalignant albumin-accumulating population in mouse tumors and exhibit the highest per-cel...