Author

Chuting Xu

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Open access Jul 2026

Targeted degradation of hepatic KEAP1 mitigates drug-induced liver injury via dual boosting NRF2 and PGAM5 signaling

Oxidative stress and impaired mitochondrial homeostasis are critical drivers of drug-induced liver injury (DILI), both of which are negatively regulated by Kelch-like ECH-associated protein 1 (KEAP1). In this study, a dual-action strategy was adapted to develop a novel KEAP1 degrader with high liver exposure for mitiga...

Yanyan Deng, Leizhi Xu, Xiaoting Niu et al. · Redox Biology · 0 citations

Aug 2026

Astragalus polysaccharides ameliorate irinotecan-induced gut toxicity by regulating gut microbiota and suppressing the MAPK signaling.

Findings suggest that APS, the key active fraction of AM against IGT, mitigate IGT by modulating microbiota-metabolite-MAPK axis, offering novel mechanistic insight for the ethnopharmacological use of AM to mitigate chemotherapy-induced intestinal toxicity.

Bolin Wu, Chenyang Zhou, Chu-Ting Xu et al. · Journal of Ethnopharmacology · 0 citations