Chu-Tong Zang

Physiologically adaptive prodrug liposomal nanoplatform enables programmable biointerface switching to potentiate cold tumor immunotherapy.

The positively charged surface underpins the biointerface activity of cationic liposomes, enabling electrostatic membrane engagement, enhanced cellular internalization, and efficient intracellular delivery. However, its premature exposure during circulation compromises delivery efficiency and increases systemic toxicit...